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This article talks about the whitewashing of anime shows turned into hollywood films and the problem with hiring a white cast to play obvious Japanese characters. I think this is a real issue and I do not think you should change the art of an anime especially because there are die hard fans out there who will notice minute details of changes and it will leave a bitter taste in the mouths of these people including the regular core fans of the anime. I believe even if a "white dude" looks so much like the character in the anime that you should not cast him, instead you should try to find a Japanese actor to play the character that looks as much as the character as one can find. I also do not think that you should hire a "white dude" to play even a character in an anime that is supposed to be "white" although this is probably the only exception, the reason for this is because the actual voice actors in these anime shows are usually Japanese since the Art of Anime is Japanese, therefore you shouldn't alter the actor to be "white / a different race" because the voice would be highly different.

https://medium.com/the-n-word/no-white-people-will-star-in-the-fullmetal-alchemist-movie-and-that-s-a-beautiful-thing-9ca20c930779